The Musculoskeletal Syndrome of Menopause

Why Your Joints Hurt More in Midlife (and What Actually Helps)

If you're a woman in your 40s or 50s and you've noticed your joints have started to ache, your shoulder has mysteriously seized up, or that nagging hip pain just won't budge — you're not imagining it, and you're not alone.


There's a name for this cluster of symptoms: the musculoskeletal syndrome of menopause. Coined by Orthopaedic surgeon Dr Vonda Wright, it's a relatively new term in the physiotherapy and medical world that describes something women have been quietly putting up with for generations — the wave of joint pain, tendon problems, muscle loss, and stiffness that often arrives alongside perimenopause and continues through the menopausal transition.


The good news? This isn't something you simply have to "push through." It's well understood, it's treatable,

and physiotherapy has a strong evidence base for managing almost every part of it.


What Is the Musculoskeletal Syndrome of Menopause?

Most of us associate menopause with hot flushes, sleep disturbance, and mood changes. But joint and muscle pain is just as common — in fact, in large studies of perimenopausal women, joint aches are consistently reported as one of the most frequent symptoms, right up there with fatigue and hot flushes.


More than 70% will experience musculoskeletal symptoms and 25% will be disabled by them through the transition from perimenopause to post menopause.


The reason comes down to oestrogen. This hormone does far more than regulate the reproductive cycle — it plays a significant role in maintaining:

  • Cartilage health — oestrogen helps keep cartilage hydrated and has anti-inflammatory effects
  • Tendon strength and elasticity — declining oestrogen reduces collagen synthesis, making tendons stiffer and more vulnerable to injury
  • Muscle mass and strength — oestrogen loss accelerates sarcopenia (age-related muscle loss)
  • Bone density — the years around menopause see the most rapid bone loss of a woman's life
  • Connective tissue integrity — affecting everything from joint capsules to pelvic floor support


When oestrogen drops during perimenopause and menopause, all of these systems are affected at once — which is why so many women experience multiple MSK issues in the same few years, sometimes seemingly out of nowhere.


The Most Common Conditions We See

At Movement for Life Physiotherapy, this is a pattern we see regularly across our Coconut Grove and Rosebery clinics. Here are the conditions most strongly linked to the perimenopausal and menopausal transition (you can click on links where available for more information on specific conditions - they're well worth a read if you have any of these symptoms):


  • Generalised Joint Aches (Polyarthralgia)

Diffuse, multi-joint aching — often in the hands, knees, and shoulders — is one of the most commonly reported menopausal symptoms. It's not always linked to a specific injury, which can make it confusing and frustrating to live with.


The incidence of frozen shoulder spikes sharply in women aged 40 to 60, and researchers increasingly suspect a hormonal link beyond the well-known diabetes connection. It can be slow to resolve without the right management.


This is one of the clearest examples of the oestrogen-tendon connection. Lateral hip pain disproportionately affects women aged 40-60, and reduced collagen synthesis around menopause is thought to be a major contributing factor.


Like the glutes, the rotator cuff tendons appear to lose resilience to load as oestrogen declines, making shoulder tendon pain more common in this life stage.


Postmenopausal women show notably higher rates of osteoarthritis than premenopausal women of a similar age.


  • Sarcopenia (Muscle Loss)

Often overlooked, but arguably one of the most important pieces of this puzzle. Muscle mass and strength decline more rapidly around menopause, which in turn increases joint loading and fall risk — and this is exactly where physiotherapy-led strength training has its biggest impact.


Already common in this age bracket, but changes in disc hydration, core and pelvic floor function, and bone density can all compound the picture during menopause.


  • Bone Density Loss and Fracture Risk (Osteopenia and Osteoporosis)

The years immediately around menopause see the fastest bone loss most women will ever experience, increasing fracture risk and contributing to vertebral and general musculoskeletal pain.


Why Physiotherapy Is So Effective Here

The encouraging part of this story is that the musculoskeletal syndrome of menopause responds extremely well to the right kind of physiotherapy care. This isn't about "just exercising more" in a vague sense — it's about targeted, evidence-based approaches:


  • Progressive resistance and exercise therapy is the single most evidence-supported strategy across nearly every condition listed above — for tendons, joints, bone density, and muscle mass alike.


  • Manual therapy can provide valuable short-term pain relief and improved range of motion, particularly for hip and knee OA and neck or back-related stiffness.


  • Clinical pilates offers a controlled, progressive way to rebuild strength, core control, and joint stability without aggravating sensitive tendons or joints.


  • Hydrotherapy is particularly useful where load tolerance is reduced, allowing strengthening and movement with significantly less joint stress.


  • Dry needling can be a helpful adjunct for managing myofascial pain and trigger points associated with some of these conditions.


The key is early, accurate diagnosis.


Many women live with these symptoms for years, assuming they're simply "getting older," when in fact a structured physiotherapy program could meaningfully change their trajectory — particularly when it comes to preserving muscle mass and bone density, which matters for decades beyond menopause itself.


What You Can Do Now

If any of this sounds familiar, the most useful first step is simply getting an accurate diagnosis. Joint and tendon pain in this life stage can have several overlapping causes, and the right management plan depends on knowing exactly what's going on.


A good physiotherapy assessment will look at:

  • Which specific structures are involved (joint, tendon, muscle, or a combination)
  • Your current strength, mobility, and movement patterns
  • Your broader health context, including bone health and activity history
  • A tailored plan — which might include exercise therapy, manual therapy, clinical pilates, hydrotherapy, or a combination of these


You don't need to just live with this.

The musculoskeletal syndrome of menopause is real, it's common, and — most importantly — it's manageable.

The Musculoskeletal Syndrome of Menopause


Frequently Asked Questions

  • What exactly is the musculoskeletal syndrome of menopause — is it a new condition?

    It's a newly named condition, but not a new experience. The term was formally introduced in 2024 to describe the collective musculoskeletal symptoms — joint pain, muscle loss, bone density decline, and progression of conditions like osteoarthritis — that are largely driven by oestrogen loss during the menopausal transition. Researchers created the term because these symptoms were consistently being treated in isolation, when in reality they share a common hormonal cause and are better understood and managed together.

  • How common is it — will I definitely get it?

    It's very common, though severity varies widely. An estimated 70% of midlife women will experience the musculoskeletal syndrome of menopause, with around 25% experiencing severe symptoms. Importantly, 40% of women who experience it will have no structural findings on imaging — meaning scans may look normal even when symptoms are significant. This is one reason it has historically been dismissed or misdiagnosed.

  • My joints ache, I feel stiff in the mornings, and I keep getting new injuries. Could this be related to menopause?

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  • Is this just normal ageing, or is oestrogen specifically to blame?

    Both are factors, but oestrogen plays a more specific role than most people realise. Oestradiol — the most potent form of oestrogen — is a powerful anti-inflammatory hormone that reduces joint pain and inflammation, helps prevent the breakdown of bone tissue, and repairs and maintains muscle. When oestradiol levels fall sharply at menopause, all of these protective effects weaken simultaneously. This is distinct from general ageing, which happens more gradually. The rapid, clustered nature of musculoskeletal symptoms around the menopausal transition is a hormonal signature, not simply the passage of time.

  • What types of physiotherapy treatment are most effective?

    Exercise is universally agreed upon as the most potent non-pharmacological treatment available, with benefits spanning muscle strength, bone density, fall risk reduction, pain management, and mood. For the musculoskeletal syndrome of menopause specifically, the most evidence-supported approaches include progressive resistance and strengthening exercise, clinical pilates for controlled joint loading and core stability, hydrotherapy for those with significant pain or load intolerance, manual therapy for stiff joints and associated soft tissue pain, and dry needling for myofascial pain and trigger points. The right combination depends on which conditions are most prominent for you — which is why an individual assessment matters more than a generic program.

  • Can I prevent these symptoms, or is it too late to do anything once they've started?

    Both prevention and late-stage intervention are meaningful. Whether you are in your 20s or 60s, it is important to be aware of the hormonal changes that occur with oestrogen decline and what you can do to be proactive. The earlier resistance training is part of your routine, the more muscle and bone reserve you bring into the menopausal transition. But equally, resistance training even later in life has been shown to slow bone loss, improve posture, reduce the likelihood of imbalance and falls, and support joint health. It is never too late to benefit meaningfully from the right exercise program.

  • Should I talk to my GP about hormone replacement therapy (HRT) for my joint and muscle symptoms?

    Yes — it's a conversation worth having. Hormone treatment may help reduce joint pain during perimenopause and menopause, and some studies show it may help bolster muscle health and strength. Prescribing hormone therapy can sometimes help clinicians pinpoint the diagnosis, as musculoskeletal symptoms that improve with oestrogen therapy suggest a hormonal driver. HRT is not appropriate for everyone, and the decision involves an individual assessment of your health history and risk profile — but if your MSK symptoms are significantly affecting your quality of life, it deserves a place in your conversation with your GP.

  • Is this the same as fibromyalgia? The symptoms sound similar.

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  • Why have I never heard of this before? Why didn't my doctor mention it?

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  • What should I do first if I think I have the musculoskeletal syndrome of menopause?

    Start with an accurate assessment. Many of the conditions that fall under this umbrella — tendinopathy, osteoarthritis, sarcopenia, frozen shoulder — have specific and distinct management requirements, so a correct diagnosis is the foundation for effective treatment. A physiotherapy assessment will identify which structures are involved, how your strength and movement are affected, and what combination of exercise therapy, manual therapy, clinical pilates, or hydrotherapy is most appropriate for you. In parallel, a conversation with your GP about your broader hormonal health is worth pursuing, particularly if hot flushes, sleep disruption, or mood changes are also present. The two conversations complement each other — one addresses the local musculoskeletal picture, the other addresses the systemic hormonal environment driving it.

Ready to get on top of your symptoms?


Get in touch with our team at Coconut Grove or Rosebery to book an assessment, and let's build a plan that keeps you strong, active, and pain-free through this life stage and beyond.


Give us a call now or click on BOOK AN APPOINTMENT to book online.


This article is general information only and does not replace individual clinical assessment. If you're experiencing joint or muscle pain, book an appointment with one of our physiotherapists for a tailored assessment and treatment plan.


Sources

  1. Anekwe, C. V., Cano, A., Mulligan, J., Ang, S. B., Johnson, C. N., Panay, N., … Nappi, R. E. (2025). The role of lifestyle medicine in menopausal health: a review of non-pharmacologic interventions. Climacteric, 28(5), 478–496. https://doi.org/10.1080/13697137.2025.2548806
  2. Frizziero, A., Vittadini, F., Gasparre, G., & Masiero, S. (2014). Impact of oestrogen deficiency and aging on tendon: Concise review. Muscles, Ligaments and Tendons Journal, 4(3), 324–328. https://pmc.ncbi.nlm.nih.gov/articles/PMC4241423/
  3. Gulati, M., Dursun, E., Vincent, K., & Watt, F. E. (2025). Impact of aging and estrogen deficiency on extracellular matrix-related gene expression in rotator cuff tendons: In vitro and in vivo rat model. ScienceDirect. https://doi.org/10.1016/j.xjoi.2025.100088
  4. Gulati, M., Dursun, E., Vincent, K., & Watt, F. E. (2023). The influence of sex hormones on musculoskeletal pain and osteoarthritis. The Lancet Rheumatology, 5(4), e225–e238. https://doi.org/10.1016/S2665-9913(23)00060-7
  5. Kruse, C., McKechnie, T., Dworsky-Fried, J., Sardar, A., Hacker, G., Rattansi, S., Fang, E., Sprague, S., Shea, A. K., & Bhandari, M. (2026). Musculoskeletal Manifestations of Perimenopause: A Systematic Review and Meta-Analysis of 93,021 Women. JB & JS open access, 11(1), e25.00254. https://doi.org/10.2106/JBJS.OA.25.00254
  6. Lu, C., Liu, P., Zhou, Y., Meng, F., Qiao, T., Yang, X., Li, X., Xue, Q., Xu, H., Liu, Y., Han, Y., & Zhang, Y. (2020). Musculoskeletal pain during the menopausal transition: A systematic review and meta-analysis. Neural Plasticity, 2020, Article 8842110. https://doi.org/10.1155/2020/8842110
  7. Moreira, L. D. F., Oliveira, M. L., Lirani-Galvão, A. P., Marin-Mio, R. V., Santos, R. N., & Lazaretti-Castro, M. (2024). Effects of exercise on bone density and physical performance in postmenopausal women: A systematic review and meta-analysis. PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC11626542/
  8. Panay, N., Fenton, A., Hamoda, H., Hillard, T., Islam, R., … Pedder, H. (2025). International Menopause Society (IMS) recommendations and key messages on women’s midlife health and menopause. Climacteric, 28(6), 634–656. https://doi.org/10.1080/13697137.2025.2585487
  9. Wang, Z., Zan, X., Li, Y., Lu, Y., Xia, Y., & Pan, X. (2023). Comparative efficacy of different resistance training protocols on bone mineral density in postmenopausal women: A systematic review and network meta-analysis. Frontiers in Physiology, 14, Article 1105303. https://doi.org/10.3389/fphys.2023.1105303
  10. Williams, J. A. E., Chester-Jones, M., Lowe, C. M., & colleagues. (2022). Hormone replacement therapy (conjugated oestrogens plus bazedoxifene) for post-menopausal women with symptomatic hand osteoarthritis: Primary report from the HOPE-e randomised, placebo-controlled, feasibility study. The Lancet Rheumatology, 4, e725–e737. https://doi.org/10.1016/S2665-9913(22)00218-1
  11. Wright, V. J., Schwartzman, J. D., Itinoche, R., & Wittstein, J. (2024). The musculoskeletal syndrome of menopause. Climacteric, 27(5), 466–472. https://doi.org/10.1080/13697137.2024.2380363
  12. Zhou, Y., Wen, K., Zhang, X., & Sun, Y. (2026). Effects of resistance training on muscle mass, strength, and physical function in older women with sarcopenia: A systematic review and meta-analysis. Frontiers in Public Health, 13, Article 1735899. https://doi.org/10.3389/fpubh.2025.1735899
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